SCHEMBL8486273

SCHEMBL8486273

Cc1c(Oc2ccc(CCCO)cc2)cccc1C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPAR1 Q92633 10/20 0.49
ALDH1A1 P00352 2/20 0.47
POLB P06746 1/20 0.47
GAA P10253 1/20 0.47
CRHBP P24387 1/20 0.47
FNTA P49354 1/20 0.47
FNTB P49356 1/20 0.47
CRHR2 Q13324 1/20 0.47
PPARA Q07869 2/20 0.47
LPAR3 Q9UBY5 1/20 0.46
LTA4H P09960 1/20 0.43
EPHX2 P34913 1/20 0.43
LPAR5 Q9H1C0 3/20 0.43
AGTR1 P30556 1/20 0.43
AGTR2 P50052 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
PPARG P37231 1/20 0.43
PPARD Q03181 1/20 0.43
PTGER1 P34995 1/20 0.42
PTGS2 P35354 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20503331 0.90 LPAR1 (0.52) LPAR1ALDH1A1POLBGAACRHBP
SCHEMBL8486209 0.87 CYP4A11 (0.52) LPAR1ALDH1A1POLBGAACRHBP
Hydrocinnamyl Alcohol SCHEMBL27417497 0.80 SMN1; SMN2 (0.48) LPAR1ALDH1A1LTA4HEPHX2SMN1; SMN2
SCHEMBL1998412 0.80 ALDH1A1 (0.58) ALDH1A1POLBGAACRHBPFNTA
SCHEMBL30657231 0.80 LTA4H (0.43) LPAR1POLBPPARALTA4HEPHX2
SCHEMBL26636357 0.80 LTA4H (0.43) LPAR1POLBPPARALTA4HEPHX2
SCHEMBL4160313 0.78 AGTR1 (0.59) LPAR1ALDH1A1PPARALPAR3LPAR5
SCHEMBL10823623 0.78 LPAR1 (0.47) LPAR1POLBPPARALPAR3LPAR5
SCHEMBL11138429 0.77 ALDH1A1 (0.53) ALDH1A1POLBGAACRHBPFNTA
SCHEMBL8625472 0.76 LPAR1 (0.52) LPAR1ALDH1A1PPARALTA4HEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5917057-A USEFUL AS ANALGESICS AND TOPICAL ANTIINFLAMMATORY AGENTS HOECHST MARION ROUSSEL, INC. (US) 1999-06-29 US disclosed
US-5840749-A ANALGESICS, INHIBITORS OF CYCLOOXYGENASE AND/OR LIPOXYGENASE, TREATMENT OF DERMATOSES HOECHST MARION ROUSSEL, INC. (US) 1998-11-24 US disclosed