Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRY1 | Q16526 | 6/20 | 0.53 |
| ▸ | CRY2 | Q49AN0 | 6/20 | 0.53 |
| ▸ | PER2 | O15055 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489557 | 0.90 | PER2 (0.55) | CRY1CRY2PER2SMN1; SMN2BACE1 | |
| SCHEMBL8489489 | 0.87 | CRY1 (0.60) | CRY1CRY2PER2SMN1; SMN2BACE1 | |
| SCHEMBL9004296 | 0.87 | PER2 (0.43) | CRY1CRY2PER2SMN1; SMN2BACE1 | |
| SCHEMBL8491767 | 0.81 | PER2 (0.39) | CRY1CRY2PER2ALDH1A1L3MBTL1 | |
| SCHEMBL8487896 | 0.80 | BACE1 (0.44) | CRY1CRY2PER2BACE1ALDH1A1 | |
| SCHEMBL8488600 | 0.79 | PER2 (0.38) | CRY1CRY2PER2ALDH1A1L3MBTL1 | |
| SCHEMBL8491775 | 0.79 | PER2 (0.47) | CRY1CRY2PER2ALDH1A1L3MBTL1 | |
| SCHEMBL8487214 | 0.79 | PER2 (0.38) | CRY1CRY2PER2ALDH1A1L3MBTL1 | |
| SCHEMBL9004331 | 0.78 | PER2 (0.47) | CRY1CRY2PER2 | |
| SCHEMBL8487231 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1RORCPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919431-A | 1,4,7,10-tetraazacyclododecane derivatives, their use, pharmaceutical agents containing these compounds and process for their production | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-07-06 | — | — | US | disclosed |