Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489560 | 0.91 | ALDH1A1 (0.37) | SMN1; SMN2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL8489492 | 0.87 | MAPK1 (0.40) | MAPK1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL8484817 | 0.85 | MAPK1 (0.38) | MAPK1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL8491771 | 0.83 | SIGMAR1 (0.35) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8491780 | 0.82 | MEN1 (0.33) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8488604 | 0.81 | MEN1 (0.33) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8487218 | 0.81 | MEN1 (0.33) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8488416 | 0.76 | ALDH1A1 (0.39) | SMN1; SMN2MAPK1GAAALDH1A1MEN1 | |
| SCHEMBL8487228 | 0.76 | CRY1 (0.53) | SMN1; SMN2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL8487226 | 0.72 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPK1GAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919431-A | 1,4,7,10-tetraazacyclododecane derivatives, their use, pharmaceutical agents containing these compounds and process for their production | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-07-06 | — | — | US | disclosed |