Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.56 |
| ▸ | CTSB | P07858 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554879 | 0.76 | ALDH1A1 (0.42) | CTSLCTSBALDH1A1HPGDKDM4E | |
| SCHEMBL29118690 | 0.75 | CTSL (0.74) | CTSLCTSBALDH1A1HPGDKDM4E | |
| SCHEMBL8487989 | 0.74 | ACHE (0.49) | CTSLCTSBALDH1A1HPGDKDM4E | |
| SCHEMBL13519624 | 0.72 | L3MBTL1 (0.50) | CTSLCTSBALDH1A1HPGDKDM4E | |
| SCHEMBL17348447 | 0.72 | ALOX5 (0.44) | CTSLCTSBALDH1A1HPGDKDM4E | |
| SCHEMBL4913124 | 0.69 | ALDH1A1 (0.54) | CTSLCTSBALDH1A1HPGDKDM4E | |
| SCHEMBL11208689 | 0.69 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL15171312 | 0.67 | APEX1 (0.57) | CTSLCTSBALDH1A1HPGDKDM4E | |
| SCHEMBL10704431 | 0.67 | KDM4E (0.45) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL15984237 | 0.67 | CTSL (0.39) | CTSLCTSBALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889018-A | ADMINISTERING TO THE PATIENT SUFFERING FROM ANXIETY A 1-STYRYLISOQUINOLINE COMPOUND AS AN ANXIOLYTIC AGENT | EGIS GYOGYSZERGYAR RT. (HU) | 1999-03-30 | — | — | US | disclosed |
| EP-0680953-A1 | 1-[Styryl]- and 1-[2'-(heteroaryl)-ethenyl]-isoquinoline derivatives, a process for preparing them as well as medicaments containing them and the use of them | EGIS GYOGYSZERGYAR RT. (HU) | 1995-11-08 | — | — | EP | disclosed |