Phthalimide

Phthalimide

SCHEMBL8488333

Nc1ccc(S(=O)(=O)O)cc1.O=C1NC(=O)c2ccccc21

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.62
ALDH1A1 P00352 4/20 0.62
NT5E P21589 1/20 0.62
GSK3B P49841 1/20 0.52
CASP7 P55210 2/20 0.50
CASP3 P42574 1/20 0.50
CASP2 P42575 1/20 0.50
CASP6 P55212 1/20 0.50
CASP8 Q14790 1/20 0.50
SMN1; SMN2 Q16637 3/20 0.45
TDP1 Q9NUW8 4/20 0.42
HSD17B10 Q99714 1/20 0.42
LMNA P02545 4/20 0.41
CYP3A4 P08684 3/20 0.41
CYP2C9 P11712 2/20 0.41
MPO P05164 1/20 0.41
HTR6 P50406 1/20 0.41
POLB P06746 3/20 0.41
CYP2D6 P10635 1/20 0.41
CA1 P00915 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalimide SCHEMBL30722317 0.85 SMN1; SMN2 (0.64) TSHRALDH1A1GSK3BCASP7CASP3
Phthalimide SCHEMBL219747 0.85 SMN1; SMN2 (0.64) TSHRALDH1A1GSK3BCASP7CASP3
Phthalimide SCHEMBL6407632 0.83 GSK3B (0.75) TSHRALDH1A1GSK3BCASP7CASP3
Phthalimide SCHEMBL217178 0.83 CASP3 (0.55) TSHRALDH1A1GSK3BCASP7CASP3
Aniline SCHEMBL11711110 0.79 TSHR (0.82) TSHRALDH1A1NT5ESMN1; SMN2TDP1
Phthalimide SCHEMBL29217853 0.79 GSK3B (0.75) TSHRALDH1A1GSK3BCASP7CASP3
Phthalimide SCHEMBL27968411 0.79 GSK3B (0.75) TSHRALDH1A1GSK3BCASP7CASP3
Benzene SCHEMBL27671391 0.79 TSHR (0.90) TSHRALDH1A1NT5ESMN1; SMN2TDP1
SCHEMBL482994 0.79 TSHR (1.00) TSHRALDH1A1NT5ECASP6SMN1; SMN2
SCHEMBL30495973 0.79 TSHR (1.00) TSHRALDH1A1NT5ECASP6SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11174670-A None JP disclosed
JP-H11174670-A RESIST MATERIAL NEC CORP 1999-07-02 JP disclosed