Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489922 | 0.83 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL8488562 | 0.82 | ALDH1A1 (0.35) | ALDH1A1SIGMAR1LMNA | |
| SCHEMBL8488750 | 0.82 | — | — | |
| SCHEMBL8491774 | 0.70 | — | — | |
| SCHEMBL8489492 | 0.69 | MAPK1 (0.40) | MAPK1POLBMEN1ALDH1A1KMT2A | |
| SCHEMBL8489489 | 0.63 | CRY1 (0.60) | POLBMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL12680198 | 0.60 | ALDH1A1 (0.71) | POLBMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3113817 | 0.60 | ALDH1A1 (0.46) | MAPK1POLBMEN1ALDH1A1KMT2A | |
| SCHEMBL8484814 | 0.60 | CRY1 (0.49) | POLBMEN1ALDH1A1KMT2ARORC | |
| SCHEMBL13185789 | 0.59 | SIGMAR1 (0.72) | MAPK1MEN1ALDH1A1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919431-A | 1,4,7,10-tetraazacyclododecane derivatives, their use, pharmaceutical agents containing these compounds and process for their production | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-07-06 | — | — | US | disclosed |