Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 17/20 | 0.34 |
| ▸ | MMP2 | P08253 | 11/20 | 0.32 |
| ▸ | MMP13 | P45452 | 4/20 | 0.31 |
| ▸ | MMP14 | P50281 | 3/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | MMP12 | P39900 | 2/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8494209 | 0.92 | ADAMTS5 (0.35) | MMP9ADAMTS5MMP2MMP13MMP14 | |
| SCHEMBL8493598 | 0.87 | ADAMTS5 (0.38) | MMP9ADAMTS5MMP2MMP13MMP14 | |
| SCHEMBL8524338 | 0.85 | TDP1 (0.35) | ADAMTS5MMP2 | |
| SCHEMBL8497338 | 0.84 | MMP2 (0.36) | MMP9ADAMTS5MMP2MMP13MMP3 | |
| SCHEMBL8495204 | 0.83 | MMP2 (0.38) | MMP9MMP2MMP13MMP3MMP8 | |
| SCHEMBL8494662 | 0.83 | ADAMTS5 (0.39) | ADAMTS5MMP2 | |
| SCHEMBL8495085 | 0.82 | ADAMTS5 (0.34) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL8491013 | 0.79 | ADAMTS7 (0.34) | MMP9ADAMTS5MMP2MMP13MMP14 | |
| SCHEMBL8496566 | 0.78 | GRM2 (0.41) | ADAMTS5MMP2MMP13MMP14ADAMTS4 | |
| SCHEMBL8491377 | 0.78 | ADAMTS5 (0.40) | ADAMTS5MMP2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |