Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497338 | 0.96 | MMP2 (0.36) | TDP1ADAMTS5MMP2 | |
| SCHEMBL8495204 | 0.95 | MMP2 (0.38) | TDP1MMP2 | |
| SCHEMBL8495085 | 0.92 | ADAMTS5 (0.34) | TDP1ADAMTS5MMP2ADAMTS7 | |
| SCHEMBL8490968 | 0.85 | MMP9 (0.34) | ADAMTS5MMP2 | |
| SCHEMBL8494209 | 0.82 | ADAMTS5 (0.35) | ADAMTS5LMNAMMP2ADAMTS7 | |
| SCHEMBL8496566 | 0.81 | GRM2 (0.41) | ADAMTS5MMP2KMT2A | |
| SCHEMBL8494134 | 0.80 | GRM2 (0.35) | TDP1ADAMTS5MMP2 | |
| SCHEMBL8495956 | 0.80 | GRM2 (0.42) | ADAMTS5KMT2A | |
| SCHEMBL8494662 | 0.79 | ADAMTS5 (0.39) | ADAMTS5MMP2ADAMTS7 | |
| SCHEMBL8491109 | 0.78 | GRM2 (0.39) | ADAMTS5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |