Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | NAAA | Q02083 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497338 | 0.99 | MMP2 (0.36) | MMP2MMP9MMP3MMP8MMP13 | |
| SCHEMBL8524338 | 0.95 | TDP1 (0.35) | MMP2TDP1 | |
| SCHEMBL8490968 | 0.83 | MMP9 (0.34) | MMP2MMP9MMP3MMP8MMP13 | |
| SCHEMBL8494209 | 0.80 | ADAMTS5 (0.35) | MMP2MMP9MMP3MMP8MMP13 | |
| SCHEMBL8496566 | 0.79 | GRM2 (0.41) | MMP2MMP3MMP13ALDH1A1 | |
| SCHEMBL8494134 | 0.78 | GRM2 (0.35) | MMP2NAAATDP1 | |
| SCHEMBL8491375 | 0.75 | ADAMTS5 (0.40) | MMP2MMP3MMP13 | |
| SCHEMBL8494212 | 0.74 | ADAMTS5 (0.33) | MMP2 | |
| SCHEMBL8493137 | 0.73 | ADAMTS5 (0.33) | MMP2MMP9MMP3MMP8MMP13 | |
| SCHEMBL8495190 | 0.73 | ADAMTS5 (0.37) | MMP2MMP9MMP3MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |