Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504854 | 0.77 | TDP1 (0.54) | HRH3MEN1KMT2AHTR1AHTR2A | |
| SCHEMBL8500338 | 0.76 | POLB (0.60) | MEN1KMT2APOLBHTTNPSR1 | |
| SCHEMBL8506685 | 0.76 | HTR1A (0.55) | HTR1AHTR2AHTR7DRD3HTR2B | |
| SCHEMBL8501110 | 0.75 | KDM4E (0.62) | MEN1KMT2AHTR1AHTR2AHTR7 | |
| SCHEMBL6512477 | 0.74 | HRH3 (0.68) | HRH3HTR1AHTR2AHTR7DRD3 | |
| SCHEMBL8506904 | 0.74 | TDP1 (0.59) | MEN1KMT2AHTR1AHTR2AHTR7 | |
| SCHEMBL3246920 | 0.74 | MAOA (0.59) | HTR1AHTR2AHTR7DRD3HTR2B | |
| SCHEMBL13487187 | 0.74 | MAOA (0.59) | HTR1AHTR2AHTR7DRD3HTR2B | |
| SCHEMBL10035540 | 0.72 | HTR7 (0.67) | ATMMEN1KMT2AHTR7 | |
| SCHEMBL31061656 | 0.72 | HRH3 (1.00) | HRH3MEN1KMT2AHRH1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999024022-A2 | ISOQUINOLINE DERIVATIVES FOR TREATING DISORDERS ASSOCIATED WITH 5HT7 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-20 | — | — | WO | disclosed |