Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 known ✓ | Q12908 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8495677 | 0.93 | SLC10A2 (0.50) | GAASMN1; SMN2SLC10A2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL8492296 | 0.90 | SLC10A2 (0.47) | GAASMN1; SMN2SLC10A2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL9563403 | 0.80 | MAPT (0.48) | GAAPOLBSMN1; SMN2TP53SLC10A2 | |
| Hydrochloric Acid SCHEMBL8496923 | 0.75 | GAA (0.49) | GAAPOLBSMN1; SMN2TP53SLC10A2 | |
| SCHEMBL8132011 | 0.74 | MAPT (0.60) | GAAPOLBSMN1; SMN2TP53SLC10A2 | |
| SCHEMBL8496920 | 0.74 | GAA (0.47) | GAAPOLBSMN1; SMN2TP53SLC10A2 | |
| Diethylamine SCHEMBL8886505 | 0.73 | GAA (0.63) | GAAPOLBSMN1; SMN2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL8136074 | 0.72 | SLC10A2 (0.52) | GAASMN1; SMN2SLC10A2MAPTMEN1 | |
| SCHEMBL8886500 | 0.72 | GAA (0.52) | GAAPOLBSMN1; SMN2TP53SLC10A2 | |
| Hydrochloric Acid SCHEMBL8133597 | 0.71 | MAPT (0.45) | GAAPOLBSMN1; SMN2TP53SLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948782-A | ANTIINFLAMMATORY AGENT; RHEUMATIC DISEASES | TAKEDA CHEMICAL (JP) | 1999-09-07 | — | — | US | disclosed |
| US-5852039-A | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5719157-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |