Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 known ✓ | Q12908 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8136074 | 0.92 | SLC10A2 (0.52) | MAPTKDM4EGAASLC10A2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8131473 | 0.89 | SLC10A2 (0.49) | MAPTKDM4EGAASLC10A2SMN1; SMN2 | |
| SCHEMBL8132011 | 0.83 | MAPT (0.60) | MAPTKDM4EGAAPOLBSLC10A2 | |
| SCHEMBL8886500 | 0.81 | GAA (0.52) | MAPTKDM4EGAAPOLBSLC10A2 | |
| Hydrochloric Acid SCHEMBL8496928 | 0.80 | GAA (0.44) | MAPTKDM4EGAAPOLBSLC10A2 | |
| Hydrochloric Acid SCHEMBL8133597 | 0.79 | MAPT (0.45) | MAPTKDM4EGAAPOLBSLC10A2 | |
| SCHEMBL7820772 | 0.79 | GAA (0.50) | MAPTKDM4EGAAPOLBSLC10A2 | |
| Hydrochloric Acid SCHEMBL8496923 | 0.78 | GAA (0.49) | MAPTKDM4EGAAPOLBSLC10A2 | |
| SCHEMBL8132831 | 0.78 | KDM4E (0.50) | MAPTKDM4EGAAPOLBSLC10A2 | |
| SCHEMBL8496920 | 0.77 | GAA (0.47) | MAPTKDM4EGAAPOLBSLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567107-A1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |