Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 7/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8496435 | 0.89 | CASP1 (0.36) | MEN1GFERKMT2ACASP1CNR1 | |
| SCHEMBL7390761 | 0.88 | KDM4E (0.42) | CASP1CNR1CNR2TSHRPTGER4 | |
| SCHEMBL7389876 | 0.87 | PTGER4 (0.37) | MEN1GFERKMT2ACNR1CNR2 | |
| SCHEMBL7200870 | 0.83 | CASP3 (0.36) | MEN1KMT2ATSHRPTGER4 | |
| SCHEMBL27564717 | 0.80 | CNR1 (0.38) | MEN1GFERKMT2ACNR1CNR2 | |
| SCHEMBL8499206 | 0.79 | CNR1 (0.36) | MEN1GFERKMT2ACNR1CNR2 | |
| SCHEMBL5670832 | 0.78 | CASP3 (0.44) | CASP1 | |
| SCHEMBL7390106 | 0.78 | PTGER4 (0.34) | MEN1KMT2ACNR1PTGER4SRC | |
| SCHEMBL8501439 | 0.77 | TRPA1 (0.51) | MEN1KMT2ACNR2 | |
| SCHEMBL7201731 | 0.77 | CASP3 (0.43) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877197-A | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases | CONATUS PHARMACEUTICALS, INC. | 1999-03-02 | — | — | US | disclosed |