Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.68 |
| ▸ | PGR | P06401 | 5/20 | 0.68 |
| ▸ | AR | P10275 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SHBG | P04278 | 1/20 | 0.51 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499697 | 1.00 | HIF1A (0.68) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL11313619 | 0.92 | PGR (0.68) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL11311598 | 0.92 | PGR (0.68) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL11311611 | 0.92 | PGR (0.68) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL11778094 | 0.92 | HIF1A (0.60) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL11778078 | 0.92 | HIF1A (0.60) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL11778799 | 0.90 | HIF1A (0.64) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL11778780 | 0.90 | HIF1A (0.64) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL9272808 | 0.89 | ABCB11 (0.59) | HIF1ACYP3A4NR3C1PGRAR | |
| SCHEMBL9272798 | 0.89 | ABCB11 (0.59) | HIF1ACYP3A4NR3C1PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0374185-B1 | IMPROVED 9$g(a)-DEHALOGENATION PROCESS | THE UPJOHN COMPANY (US) | 1993-02-10 | — | — | EP | claimed |
| US-5939409-A | CONDENSATION OF ALDEHYDE WITH STEROIDIOL TO FORM AN ACETAL GROUPS | ASTRA AKTIEBOLAG (SE) | 1999-08-17 | — | — | US | disclosed |
| US-5888995-A | ANTIINFLAMMATORY AND ANTIALLERGENIC AGENTS; A NOVEL GLUCOCORTICOSTEROID | ASTRA AKTIEBOLAG (SE) | 1999-03-30 | — | — | US | disclosed |
| US-5674861-A | GLUCOCORTICOSTEROIDS FOR LOCAL TREATMENT OF INFLAMMATORY DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-10-07 | — | — | US | disclosed |
| US-5614514-A | Steroid esters | AKTIEBOLAGET ASTRA (SE) | 1997-03-25 | — | — | US | disclosed |
| US-4036831-A | Trimethyl siloxane steroid intermediates | STEROID DEVELOPMENT COMPANY ESTABLISHMENT (CH) | 1977-07-19 | — | — | US | disclosed |