Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.65 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11201118 | 0.90 | PDE3B (0.55) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL11197233 | 0.87 | POLB (0.59) | PDE3BPDE3ALMNASMN1; SMN2GAA | |
| SCHEMBL11197979 | 0.84 | LMNA (0.48) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL11200140 | 0.81 | MGLL (0.58) | KCNH2LMNASMN1; SMN2HTTMAPT | |
| SCHEMBL11201259 | 0.81 | PDE3B (0.47) | PDE3BPDE3ALMNAGAAHTT | |
| SCHEMBL11196441 | 0.81 | PDE3B (0.60) | PDE3BPDE3ALMNAGAAHTT | |
| SCHEMBL7034123 | 0.80 | PDE3B (0.66) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL9403786 | 0.80 | PDE3B (0.58) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL11200241 | 0.79 | ALDH1A1 (0.61) | LMNASMN1; SMN2GAAHTTMAPT | |
| SCHEMBL11193805 | 0.79 | SMN1; SMN2 (0.57) | PDE3BPDE3ALMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | claimed |
| EP-0552373-B1 | APOPTOSIS REGULATOR | OTSUKA PHARMA CO LTD (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5658912-A | 6-(4-(3,4-DIMETHOXYBENZOYL)-1-PIPERAZINYL)CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5543412-A | ADMINISTERING A BENZOYL PIPERAZIN QUINOLINS VIRICIDES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0552373-A1 | APOPTOSIS REGULATOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |