Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.61 |
| ▸ | PDE4A | P27815 | 7/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.55 |
| ▸ | PDE2A | O00408 | 2/20 | 0.49 |
| ▸ | PDE1A | P54750 | 2/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59949 | 0.91 | ADORA2B (0.72) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| Phosphoric Acid SCHEMBL8500178 | 0.85 | ADORA2B (0.64) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| 1-Methylxanthine SCHEMBL16859909 | 0.79 | ADORA2B (0.79) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL60158 | 0.78 | ADORA2A (0.70) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL4423680 | 0.76 | ADORA2B (1.00) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL383123 | 0.76 | ADORA2A (0.72) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL27256851 | 0.76 | ADORA2B (0.68) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL5451521 | 0.76 | ADORA2B (0.68) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| Xanthine SCHEMBL692609 | 0.74 | ADORA2B (0.54) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL6233166 | 0.74 | ADORA2B (1.00) | ADORA2BADORA2AADORA3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389736-B2 | Compounds having activity in correcting mutant-CFTR processing and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-05 | — | — | US | disclosed |
| US-20120101143-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-CFTR and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-04-26 | — | — | US | disclosed |
| US-8143295-B2 | Compounds having activity in correcting mutant-CFTR processing and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-27 | — | — | US | disclosed |
| EP-2421956-A2 | COMPOSITIONS AND METHODS FOR DERIVING OR CULTURING PLURIPOTENT CELLS | The Whitehead Institute for Biomedical Research (US) | 2012-02-29 | — | — | EP | disclosed |
| US-7939558-B2 | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-10 | — | — | US | disclosed |
| US-20110088107-A1 | COMPOSITIONS AND METHODS FOR DERIVING OR CULTURING PLURIPOTENT CELLS | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | 2011-04-14 | — | — | US | disclosed |
| US-20100273839-A1 | Compounds Having Activity in Correcting Mutant-CFTR Processing and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2010-10-28 | — | — | US | disclosed |
| WO-2010124290-A2 | COMPOSITIONS AND METHODS FOR DERIVING OR CULTURING PLURIPOTENT CELLS | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2010-10-28 | — | — | WO | disclosed |
| US-7696244-B2 | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| WO-2009051909-A1 | COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT-CFTR CELLULAR PROCESSING AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009051910-A1 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-23 | — | — | WO | disclosed |
| US-20080318984-A1 | Compounds Having Activity in Correcting Mutant-Cftr Processing and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-25 | — | — | US | disclosed |
| US-20080319008-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-25 | — | — | US | disclosed |
| EP-1765347-A4 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | UNIV CALIFORNIA (US) | 2008-10-01 | — | — | EP | disclosed |
| EP-1863522-A2 | COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT-CFTR PROCESSING AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20070265316-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-15 | — | — | US | disclosed |
| EP-1765347-A2 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | The Regents of the University of California (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006101740-A2 | COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT-CFTR PROCESSING AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-09-28 | — | — | WO | disclosed |
| WO-2005120497-A2 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265316-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | CFTR, SLC47A1, SLC47A2 | ADORA2B 714/4885ADORA2A 873/4885ADORA3 427/4885 |
| US-20080319008-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | CFTR, ABCC9, SLC26A4 | ADORA2B 672/4885ADORA2A 1114/4885ADORA3 645/4885 |
| US-20120101143-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-CFTR and Uses Thereof | CFTR, ABCC9, ABCB11 | ADORA2B 585/4885ADORA2A 979/4885ADORA3 584/4885 |
| US-20100273839-A1 | Compounds Having Activity in Correcting Mutant-CFTR Processing and Uses Thereof | CFTR, ABCC5, ABCB11 | ADORA2B 1323/4885ADORA2A 1873/4885ADORA3 213/4885 |
| US-20080318984-A1 | Compounds Having Activity in Correcting Mutant-Cftr Processing and Uses Thereof | CFTR, ABCC5, QPCT | ADORA2B 1654/4885ADORA2A 2885/4885ADORA3 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.