Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501225 | 0.94 | ESR1 (0.43) | ESR1ESR2KDM4ETDP1L3MBTL1 | |
| SCHEMBL8500327 | 0.94 | ESR1 (0.42) | ESR1ESR2SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL8498114 | 0.93 | ESR1 (0.46) | ESR1ESR2SMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL8500300 | 0.91 | CYP1A2 (0.40) | ESR1ESR2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8501370 | 0.90 | L3MBTL1 (0.48) | ESR1ESR2KDM4ETDP1L3MBTL1 | |
| SCHEMBL8497579 | 0.87 | SMN1; SMN2 (0.42) | ESR1ESR2SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL8501283 | 0.86 | ESR1 (0.52) | ESR1ESR2 | |
| SCHEMBL8497879 | 0.86 | KMT2A (0.42) | ESR1ESR2SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL7188421 | 0.84 | ESR1 (0.42) | ESR1ESR2SMN1; SMN2TDP1HSP90AA1 | |
| SCHEMBL7186100 | 0.84 | ESR1 (0.48) | ESR1ESR2SMN1; SMN2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |