Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501042 | 0.94 | ESR1 (0.40) | ESR1ESR2GRM2KDM4ETDP1 | |
| SCHEMBL8500327 | 0.90 | ESR1 (0.42) | ESR1ESR2KDM4EALDH1A1LMNA | |
| SCHEMBL8497260 | 0.89 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL8501430 | 0.88 | ESR1 (0.46) | ESR1ESR2GRM2TUBB4ATUBB | |
| SCHEMBL8500300 | 0.87 | CYP1A2 (0.40) | ESR1ESR2TDP1L3MBTL1GAA | |
| SCHEMBL8498114 | 0.87 | ESR1 (0.46) | ESR1ESR2KDM4EALDH1A1MAPT | |
| SCHEMBL8501370 | 0.85 | L3MBTL1 (0.48) | ESR1ESR2KDM4EALDH1A1MAPT | |
| SCHEMBL8501283 | 0.83 | ESR1 (0.52) | ESR1ESR2 | |
| SCHEMBL8497579 | 0.81 | SMN1; SMN2 (0.42) | ESR1ESR2GRM2KDM4EMAPT | |
| SCHEMBL7193782 | 0.80 | ESR1 (0.47) | ESR1ESR2GRM2TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |