Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.42 |
| ▸ | ITGAV | P06756 | 11/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864761 | 0.91 | ITGB3 (0.43) | ITGB3ITGAVITGA2BMEN1KMT2A | |
| SCHEMBL7863285 | 0.88 | ITGB3 (0.48) | ITGB3ITGAVITGA2BPOLBSIRT1 | |
| SCHEMBL8501217 | 0.80 | ITGB3 (0.45) | ITGB3ITGAVITGA2BMEN1KMT2A | |
| SCHEMBL7863273 | 0.78 | FFAR1 (0.43) | ITGB3ITGA2BPOLB | |
| SCHEMBL7863288 | 0.77 | SIRT2 (0.48) | ITGB3ITGA2BKMT2A | |
| SCHEMBL7856539 | 0.77 | ITGB3 (0.41) | ITGB3ITGAVMEN1KMT2A | |
| SCHEMBL7861978 | 0.76 | ITGB3 (0.35) | ITGB3ITGAVITGA2BKMT2APOLB | |
| SCHEMBL7863151 | 0.76 | KMT2A (0.57) | MEN1KMT2ASIRT1 | |
| SCHEMBL7856433 | 0.76 | ITGB3 (0.54) | ITGB3ITGA2BMEN1KMT2APOLB | |
| SCHEMBL7856431 | 0.76 | HDAC1 (0.45) | ITGB3ITGA2BMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |