Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501220 | 0.88 | ITGB3 (0.42) | ITGB3ITGA2BSIRT1POLBITGAV | |
| SCHEMBL7863273 | 0.87 | FFAR1 (0.43) | ITGB3ITGA2BMAPTLMNAPOLB | |
| SCHEMBL7862054 | 0.86 | F10 (0.52) | ITGB3ITGA2BMAPTGAALMNA | |
| SCHEMBL7864761 | 0.84 | ITGB3 (0.43) | ITGB3ITGA2BMAPTPOLBITGAV | |
| SCHEMBL7863151 | 0.84 | KMT2A (0.57) | SIRT1F10 | |
| SCHEMBL7863288 | 0.83 | SIRT2 (0.48) | ITGB3ITGA2BMAPTLMNAMAPK1 | |
| SCHEMBL7856539 | 0.83 | ITGB3 (0.41) | ITGB3MAPTLMNAITGAVALDH1A1 | |
| SCHEMBL7861978 | 0.82 | ITGB3 (0.35) | ITGB3ITGA2BMAPTGAALMNA | |
| SCHEMBL7864160 | 0.82 | FFAR1 (0.39) | ITGB3ITGA2BSIRT1LMNAITGAV | |
| SCHEMBL7856431 | 0.82 | HDAC1 (0.45) | ITGB3ITGA2BSIRT1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |