Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863285 | 0.87 | ITGB3 (0.48) | PARP1ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL7866927 | 0.83 | FFAR1 (0.45) | FFAR1HIF1AHDAC8HDAC6ITGB3 | |
| SCHEMBL7863288 | 0.83 | SIRT2 (0.48) | HDAC8HDAC6ITGB3ITGA2BMAPT | |
| SCHEMBL7856433 | 0.81 | ITGB3 (0.54) | PARP1ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL7863151 | 0.81 | KMT2A (0.57) | FFAR1 | |
| SCHEMBL7864761 | 0.79 | ITGB3 (0.43) | ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL7861944 | 0.79 | HDAC1 (0.45) | PARP1ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL7864754 | 0.79 | PTPN11 (0.48) | FFAR1PARP1ITGB3ITGA2BPOLB | |
| SCHEMBL7856431 | 0.79 | HDAC1 (0.45) | PARP1ITGB3ITGA2BPOLBMAPT | |
| SCHEMBL7856539 | 0.78 | ITGB3 (0.41) | ITGB3MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |