Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SENP1 | Q9P0U3 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864274 | 0.91 | LMNA (0.43) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7856464 | 0.89 | TP53 (0.49) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7862015 | 0.88 | MAPT (0.51) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7864169 | 0.88 | F10 (0.48) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7861969 | 0.87 | MAPK1 (0.52) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7864172 | 0.87 | TP53 (0.46) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7862019 | 0.87 | LMNA (0.45) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7856433 | 0.87 | ITGB3 (0.54) | SIRT2HTTRAB9ANPC1KMT2A | |
| SCHEMBL7864712 | 0.84 | SIRT2 (0.45) | SIRT2MAPK1LMNASENP1ALDH1A1 | |
| SCHEMBL7863196 | 0.84 | MAPT (0.50) | SIRT2MAPK1LMNAHDAC6ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |