Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501836 | 0.98 | ALDH1A1 (0.35) | RAB9ANPC1MAPTGAANFKB1 | |
| SCHEMBL11110746 | 0.90 | RAB9A (0.31) | RAB9ANPC1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL11021176 | 0.90 | RAB9A (0.31) | RAB9ANPC1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL29956971 | 0.76 | RAB9A (0.38) | RAB9ANPC1MAPTGAANFKB1 | |
| SCHEMBL12156965 | 0.75 | TDP1 (0.42) | RAB9ANPC1ALDH1A1CYP1A2MEN1 | |
| Hydrochloric Acid SCHEMBL8459940 | 0.72 | ALDH1A1 (0.36) | GAAALDH1A1MAPK1TDP1 | |
| SCHEMBL14020050 | 0.71 | TRPA1 (0.52) | RAB9ANPC1MAPTGAAALDH1A1 | |
| SCHEMBL11583621 | 0.71 | TDP1 (0.52) | RAB9ANPC1MAPTGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL8497331 | 0.70 | ALDH1A1 (0.33) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL972024 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | claimed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | claimed |
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5480791-A | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | disclosed |
| US-4394309-A | Process for the preparation of N,N-dimethyl-N-(2-bromo-4-methylphenyl)-triazene | BAYER AKTIENGESELLSCHAFT (DE) | 1983-07-19 | — | — | US | disclosed |
| EP-0037948-B1 | PROCESS FOR PREPARING N,N'-DIMETHYL-N'-(2-BROMO-4-METHYLPHENYL) TRIAZENE | BAYER AG (DE) | 1983-04-20 | — | — | EP | disclosed |