Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501517 | 0.88 | PFKFB3 (0.46) | PFKFB3TRIM24MAPTPDE4BPDE4D | |
| SCHEMBL8500583 | 0.84 | PFKFB3 (0.39) | PFKFB3MAPTPDE4BPDE4DHSD17B1 | |
| SCHEMBL8501758 | 0.84 | HTR6 (0.43) | PFKFB3MAPTHSD17B1HSD17B2MEN1 | |
| SCHEMBL8499997 | 0.82 | PFKFB3 (0.41) | PFKFB3MAPTPDE4BPDE4DHSD17B1 | |
| SCHEMBL7376815 | 0.78 | ALDH1A1 (0.55) | MAPTMEN1KMT2AHDAC4HDAC1 | |
| SCHEMBL7866912 | 0.74 | SMN1; SMN2 (0.41) | PFKFB3MAPTMEN1HPGDKMT2A | |
| SCHEMBL8371225 | 0.73 | ITGB3 (0.53) | PFKFB3MAPTMEN1KMT2ATHRB | |
| SCHEMBL8500575 | 0.73 | MEN1 (0.42) | PFKFB3MAPTHSD17B1HSD17B2MEN1 | |
| SCHEMBL7861775 | 0.72 | EEF2K (0.43) | PFKFB3MAPTMEN1HPGDKMT2A | |
| SCHEMBL8501754 | 0.72 | MEN1 (0.44) | PFKFB3MAPTHSD17B1HSD17B2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |