Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501754 | 0.88 | MEN1 (0.44) | HTR6HSD17B1HSD17B2PFKFB3PARP1 | |
| SCHEMBL7376815 | 0.85 | ALDH1A1 (0.55) | HTR6ALDH1A1FFAR1MEN1KMT2A | |
| SCHEMBL8501524 | 0.84 | PFKFB3 (0.47) | HSD17B1HSD17B2PFKFB3MEN1KMT2A | |
| SCHEMBL8499997 | 0.83 | PFKFB3 (0.41) | HTR6HSD17B1HSD17B2PFKFB3MEN1 | |
| SCHEMBL8500583 | 0.81 | PFKFB3 (0.39) | HTR6HSD17B1HSD17B2PFKFB3FFAR1 | |
| SCHEMBL8371225 | 0.79 | ITGB3 (0.53) | HTR6PFKFB3MEN1KMT2AMAPT | |
| SCHEMBL8500892 | 0.74 | PTGDR2 (0.35) | HTR6PFKFB3ALDH1A1MEN1KMT2A | |
| SCHEMBL8371139 | 0.72 | ITGB3 (0.57) | HTR6ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL14532378 | 0.72 | ITGB3 (0.57) | HTR6ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL7864756 | 0.72 | CA1 (0.38) | HTR6HSD17B1HSD17B2PFKFB3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |