Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.73 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 3/20 | 0.68 |
| ▸ | MAOA | P21397 | 2/20 | 0.68 |
| ▸ | PPARG | P37231 | 2/20 | 0.64 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.62 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.61 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503299 | 0.95 | SRD5A2 (0.77) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL402300 | 0.89 | SRD5A2 (0.87) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL3232949 | 0.87 | SRD5A2 (0.90) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL1746654 | 0.85 | FFAR1 (0.67) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL10784618 | 0.85 | RXRA (0.68) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL1369316 | 0.85 | NR4A2 (1.00) | NR4A2SMN1; SMN2SRD5A2RAB9AMAOB | |
| SCHEMBL14130003 | 0.85 | NR4A2 (0.66) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6238323 | 0.84 | ALDH1A1 (0.73) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL31556120 | 0.84 | ALDH1A1 (0.78) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL27704685 | 0.84 | RXRA (0.74) | NR4A2ALDH1A1HTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1058014-C | New heterocyclic spiro compounds, process for preparation thereof, and pharmaceutical compositions containing them | ADIR ET CO (FR) | 2000-11-01 | — | — | CN | disclosed |
| EP-0743312-B1 | Spiroheterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-11-17 | — | — | EP | disclosed |
| CN-1136568-A | New heterocyclic spiro compounds, process for preparation thereof, and pharmaceutical compositions containing them | ADIR (FR) | 1996-11-27 | — | — | CN | disclosed |
| EP-0743312-A1 | Spiroheterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-11-20 | — | — | EP | disclosed |