Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.74 |
| ▸ | RXRB | P28702 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 3/20 | 0.68 |
| ▸ | PTGES | O14684 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 2/20 | 0.64 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.61 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.61 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.61 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067849 | 0.95 | SRD5A2 (0.77) | RXRARXRBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL402300 | 0.89 | SRD5A2 (0.87) | ALDH1A1HTTSMN1; SMN2L3MBTL1SRD5A2 | |
| SCHEMBL3232949 | 0.87 | SRD5A2 (0.90) | ALDH1A1HTTSMN1; SMN2L3MBTL1SRD5A2 | |
| SCHEMBL24488963 | 0.85 | RXRA (1.00) | RXRARXRBSMN1; SMN2SRD5A2RAB9A | |
| SCHEMBL3172610 | 0.85 | RXRA (1.00) | RXRARXRBSMN1; SMN2SRD5A2RAB9A | |
| SCHEMBL8503301 | 0.84 | NR4A2 (0.74) | ALDH1A1HTTSMN1; SMN2L3MBTL1SRD5A2 | |
| SCHEMBL31556120 | 0.84 | ALDH1A1 (0.78) | ALDH1A1HTTSMN1; SMN2L3MBTL1SRD5A2 | |
| SCHEMBL6238323 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HTTSMN1; SMN2L3MBTL1SRD5A2 | |
| SCHEMBL7539817 | 0.84 | SRD5A2 (0.73) | ALDH1A1HTTSMN1; SMN2L3MBTL1SRD5A2 | |
| SCHEMBL17166051 | 0.82 | RXRA (0.62) | RXRARXRBALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105038760-A | Ophthalmic devices comprising photochromic materials having extended pi-conjugated systems | JOHNSON & JOHNSON VISION CARE | 2015-11-11 | — | — | CN | disclosed |
| CN-101203582-B | Ophthalmic devices comprising photochromic materials with extended pi-conjugated systems | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-08-19 | — | — | CN | disclosed |
| CN-104130768-A | Ophthalmic devices comprising photochromic materials having extended pi-conjugated systems | JOHNSON & JOHNSON VISION CARE | 2014-11-05 | — | — | CN | disclosed |
| CN-101203582-A | Ophthalmic devices comprising photochromic materials with extended pi-conjugated systems | JOHNSON & JOHNSON VISION CARE (US) | 2008-06-18 | — | — | CN | disclosed |