Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669816 | 0.98 | AR (0.38) | MAPTARHPGDKDM4EALDH1A1 | |
| SCHEMBL8668975 | 0.81 | AR (0.41) | MAPTARHPGDKDM4EALDH1A1 | |
| SCHEMBL8669096 | 0.78 | AR (0.41) | MAPTARHPGDKDM4EALDH1A1 | |
| SCHEMBL8439253 | 0.77 | MAPT (0.41) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8633727 | 0.76 | MAPT (0.41) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL637824 | 0.75 | KDM4E (0.47) | HPGDKDM4EALDH1A1HTTTSHR | |
| SCHEMBL8672637 | 0.71 | SMN1; SMN2 (0.37) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8504531 | 0.70 | CCR1 (0.31) | CTSD | |
| SCHEMBL8670481 | 0.70 | ALDH1A1 (0.36) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8669942 | 0.70 | LMNA (0.40) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998445-A | PEPTIC ULCERS | EISAI CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| US-5840910-A | Pyridine derivatives having anti-ulcerative activity | ESAI CO., LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0268956-A2 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1988-06-01 | — | — | EP | disclosed |