Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176783 | 0.94 | AGTR1 (0.52) | PLA2G2AAGTR1AGTR2LTB4R2DHODH | |
| SCHEMBL9181093 | 0.91 | AGTR1 (0.60) | PLA2G2AAGTR1AGTR2 | |
| SCHEMBL8505737 | 0.91 | DHODH (0.55) | AGTR1AGTR2DHODHBRS3 | |
| SCHEMBL8501790 | 0.85 | PLA2G2A (0.52) | PLA2G2AAGTR1AGTR2LTB4R2DHODH | |
| SCHEMBL9183186 | 0.85 | KDM4E (0.57) | AGTR1AGTR2DHODH | |
| SCHEMBL9176806 | 0.85 | ADAM17 (0.52) | PLA2G2ADHODH | |
| SCHEMBL9177090 | 0.82 | AGTR1 (0.63) | AGTR1AGTR2 | |
| SCHEMBL7838473 | 0.82 | NR1H4 (0.49) | AGTR1AGTR2DHODH | |
| SCHEMBL8501882 | 0.81 | MAPT (0.48) | PLA2G2AAGTR1AGTR2LTB4R2DHODH | |
| Hydrochloric Acid SCHEMBL8502040 | 0.81 | NR1H4 (0.48) | AGTR1AGTR2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004979-A | ANGIOTENSIN II INHIBITORS; 4-((CARBOXY)ARYLOXY)-QUINOLINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |