Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526453 | 0.93 | AGTR1 (0.51) | AGTR1AGTR2LTB4R2DHODH | |
| SCHEMBL8505378 | 0.81 | PLA2G2A (0.52) | AGTR1AGTR2PLA2G2ALTB4R2ACHE | |
| SCHEMBL8501790 | 0.78 | PLA2G2A (0.52) | AGTR1AGTR2PLA2G2ALTB4R2ACHE | |
| SCHEMBL9176783 | 0.77 | AGTR1 (0.52) | AGTR1AGTR2PLA2G2ALTB4R2DHODH | |
| SCHEMBL8504880 | 0.77 | AGTR1 (0.60) | AGTR1AGTR2PLA2G2ALTB4R2ACHE | |
| SCHEMBL7835618 | 0.77 | BRS3 (0.52) | AGTR1AGTR2LTB4R2DHODH | |
| SCHEMBL8979743 | 0.77 | AGTR1 (0.52) | AGTR1AGTR2LTB4R2ACHE | |
| SCHEMBL8501923 | 0.77 | AGTR1 (0.50) | AGTR1AGTR2PLA2G2ALTB4R2ACHE | |
| SCHEMBL9176806 | 0.76 | ADAM17 (0.52) | PLA2G2ADHODH | |
| SCHEMBL8584304 | 0.76 | AGTR1 (0.49) | AGTR1AGTR2PLA2G2ALTB4R2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004979-A | ANGIOTENSIN II INHIBITORS; 4-((CARBOXY)ARYLOXY)-QUINOLINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |