Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.65 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.65 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.65 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.65 |
| ▸ | F2 | P00734 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ATIC | P31939 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852134 | 0.92 | ST14 (0.76) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL3792939 | 0.88 | F2 (0.62) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851310 | 0.79 | ST14 (1.00) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL3790598 | 0.78 | PRSS1 (0.78) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL8510004 | 0.74 | PRSS1 (0.55) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL852159 | 0.74 | PRSS1 (0.65) | PRSS1PRSS2PRSS3ST14MEN1 | |
| SCHEMBL8509253 | 0.73 | PARP15 (0.47) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851450 | 0.73 | SLC22A12 (0.54) | MEN1KMT2AFFAR4FFAR1PLA2G7 | |
| SCHEMBL3792439 | 0.69 | ST14 (0.77) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851158 | 0.69 | ST14 (0.67) | PRSS1PRSS2PRSS3ST14F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | PRSS1 3/4885PRSS2 23/4885PRSS3 11/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | PRSS1 3/4885PRSS2 23/4885PRSS3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.