Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL5321413 | 0.91 | LMNA (0.33) | HDAC3HDAC1HDAC2HDAC8CYP2C19 | |
| Histamine SCHEMBL1680140 | 0.91 | LMNA (0.33) | HDAC3HDAC1HDAC2HDAC8CYP2C19 | |
| Hexanoate SCHEMBL9698455 | 0.90 | AKR1B1 (0.44) | PDE4ATSHRTDP1L3MBTL1PPARA | |
| Histamine SCHEMBL9702159 | 0.89 | HRH4 (0.36) | FFAR3CYP2C19HRH4HRH3CYP2C9 | |
| Glutarate SCHEMBL5770219 | 0.88 | LMNA (0.39) | HDAC3HDAC1HDAC2HDAC8TSHR | |
| Adipic Acid SCHEMBL11632441 | 0.88 | NFKB1 (0.42) | HDAC3HDAC1HDAC2HDAC8TSHR | |
| Histamine SCHEMBL5840054 | 0.85 | HRH4 (0.38) | CYP2C19HRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL1782847 | 0.85 | HRH4 (0.36) | CYP2C19HRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL10947437 | 0.84 | HRH4 (0.41) | CYP2C19HRH4HRH3CYP2C9TSHR | |
| Histamine SCHEMBL4234179 | 0.83 | HRH4 (0.39) | CYP2C19HRH4HRH3CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895537-A1 | IGA1 PROTEASE FRAGMENT AS CARRIER PEPTIDE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin (DE) | 1999-02-10 | — | — | EP | disclosed |
| WO-1998031791-A1 | IGA1 PROTEASE FRAGMENT AS CARRIER PEPTIDE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin (DE) | 1998-07-23 | — | — | WO | disclosed |