Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL5840054 | 0.90 | HRH4 (0.38) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL1782847 | 0.90 | HRH4 (0.36) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL8510036 | 0.89 | FFAR3 (0.39) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL5321413 | 0.88 | LMNA (0.33) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL1680140 | 0.88 | LMNA (0.33) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL4234179 | 0.88 | HRH4 (0.39) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL8887482 | 0.86 | HRH4 (0.34) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL10424806 | 0.86 | HRH4 (0.40) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL2825791 | 0.86 | HRH4 (0.33) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL28875895 | 0.86 | HRH4 (0.42) | HRH4HRH3CYP2C9TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844348-B1 | HAIR CLEANSING AND CONDITIONING COMPOSITION | OREAL (FR) | 2018-09-05 | — | — | EP | disclosed |
| EP-2844348-A1 | HAIR CLEANSING AND CONDITIONING COMPOSITION | L'Oréal (FR) | 2015-03-11 | — | — | EP | disclosed |
| US-8865147-B2 | Hair cleansing and conditioning composition | L'OREAL (FR) | 2014-10-21 | — | — | US | disclosed |
| WO-2013165799-A1 | HAIR CLEANSING AND CONDITIONING COMPOSITION | L'OREAL (FR) | 2013-11-07 | — | — | WO | disclosed |
| US-20130284198-A1 | Hair Cleansing and Conditioning Composition | L'OREAL S.A. (FR) | 2013-10-31 | — | — | US | disclosed |
| US-5112738-A | Detection of histamine release | MILES INC. (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0208953-B1 | HISTAMINE DERIVATIVES, IMMUNOGEN CONJUGATES AND ANTIBODIES RAISED THERETO | MILES INC. (US) | 1990-04-25 | — | — | EP | disclosed |
| EP-0208953-A1 | Histamine derivatives, immunogen conjugates and antibodies raised thereto | MILES INC. (US) | 1987-01-21 | — | — | EP | disclosed |