Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 7/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 7/20 | 0.32 |
| ▸ | ITGAL | P20701 | 7/20 | 0.32 |
| ▸ | PIM1 | P11309 | 4/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533222 | 0.84 | CYP2D6 (0.38) | LRRK2PIM1PIM3PIM2 | |
| SCHEMBL8515290 | 0.80 | KARS1 (0.45) | KARS1ITGB2ICAM1ITGALPIM1 | |
| Hydrochloric Acid SCHEMBL8512524 | 0.79 | KARS1 (0.44) | KARS1ITGB2ICAM1ITGALPIM1 | |
| SCHEMBL8514718 | 0.77 | KARS1 (0.46) | KARS1PIM1PIM3PIM2HTR2C | |
| SCHEMBL8514744 | 0.77 | S1PR1 (0.41) | KARS1PIM1PIM3PIM2PRKD1 | |
| Hydrochloric Acid SCHEMBL8511433 | 0.76 | KARS1 (0.45) | KARS1PIM1PIM3PIM2HTR2C | |
| Hydrochloric Acid SCHEMBL8512940 | 0.76 | S1PR1 (0.41) | KARS1PIM1PIM3PIM2PRKD1 | |
| SCHEMBL8511790 | 0.76 | ROCK2 (0.41) | LRRK2ADRB1PRKD1PRKD2 | |
| Hydrochloric Acid SCHEMBL8512525 | 0.76 | ROCK2 (0.41) | LRRK2ADRB1PRKD1PRKD2 | |
| Hydrochloric Acid SCHEMBL8511580 | 0.76 | ROCK2 (0.41) | LRRK2ADRB1PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |