SCHEMBL8510766

SCHEMBL8510766

Cc1nc(-c2ccccc2)n(-c2cccc(-c3ccccc3)c2)n1

nearest known ligand 0.62

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.47
KMT2A Q03164 1/20 0.46
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2B6 P20813 1/20 0.43
TP53 P04637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10585221 0.88 SMN1; SMN2 (0.59) SMN1; SMN2NPC1RAB9ACYP1A2CYP2C9
SCHEMBL8510613 0.86 DCTPP1 (0.48) SMN1; SMN2KMT2ACYP1A2CYP3A4CYP2D6
SCHEMBL24441105 0.77 TP53 (0.53) NPC1RAB9ACYP1A2CYP3A4CYP2D6
SCHEMBL19196204 0.77 TP53 (0.51) SMN1; SMN2NPC1RAB9ATP53
SCHEMBL19195922 0.77 SMN1; SMN2 (0.51) SMN1; SMN2KMT2ANPC1RAB9A
SCHEMBL14210107 0.75 NPC1 (0.45) NPC1RAB9A
SCHEMBL5205307 0.74 SMN1; SMN2 (0.45) SMN1; SMN2KMT2ANPC1RAB9ACYP1A2
SCHEMBL15319582 0.73 PSMB5 (0.40) SMN1; SMN2NPC1RAB9A
SCHEMBL19196710 0.73 KMT2A (0.43) SMN1; SMN2KMT2ANPC1RAB9A
SCHEMBL29533750 0.72 ALDH1A1 (0.56) SMN1; SMN2KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9666825-B2 Light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-05-30 US disclosed
US-9666825-B2 Light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-05-30 US disclosed
US-20160293877-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-10-06 US disclosed
US-20160293877-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-10-06 US disclosed
US-20120133273-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-31 US disclosed
US-20120133273-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-31 US disclosed
WO-2012070596-A1 ORGANOMETALLIC COMPLEX, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-05-31 WO disclosed
US-20120133273-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-31 US disclosed
WO-2012070596-A1 ORGANOMETALLIC COMPLEX, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120133273-A1 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device LAGE3, CRY1, CYBA SMN1; SMN2 4298/4885KMT2A 1867/4885NPC1 4038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.