Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CRHBP | P24387 | 3/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510870 | 0.95 | ALDH1A1 (0.49) | RAB9ACRHBPCRHR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11270421 | 0.90 | RAB9A (0.48) | RAB9ACRHBPCRHR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8435360 | 0.90 | RAB9A (0.48) | RAB9ACRHBPCRHR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL9300433 | 0.86 | ALDH1A1 (0.53) | RAB9AALDH1A1SMN1; SMN2NPC1ATM | |
| SCHEMBL84134 | 0.85 | ALDH1A1 (0.49) | RAB9AALDH1A1SMN1; SMN2NPC1KMT2A | |
| SCHEMBL10596789 | 0.84 | HTT (0.41) | RAB9AALDH1A1SMN1; SMN2KCNH2IDO1 | |
| SCHEMBL9522656 | 0.84 | ALDH1A1 (0.53) | RAB9AALDH1A1SMN1; SMN2NPC1MEN1 | |
| SCHEMBL8432142 | 0.84 | RAB9A (0.46) | RAB9ACRHBPCRHR2ALDH1A1NPC1 | |
| SCHEMBL10915717 | 0.84 | LMNA (0.47) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL11790891 | 0.83 | ALDH1A1 (0.48) | RAB9AALDH1A1SMN1; SMN2NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985281-A | ANTIBODY DIRECTED ENZYME PRODRUG THERAPY (ADEPT) USING A NON-NATURALLY OCCURING MUTANT FORM OF A HOST ENZYME, ESPECIALLY A MUTANT FORM OF RIBONUCLEASE. | ZENECA LIMITED (GB) | 1999-11-16 | — | — | US | disclosed |