Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 7/20 | 0.37 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | SORD | Q00796 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8513698 | 1.00 | DKK1 (0.38) | DKK1CA9CA2RARARARB | |
| SCHEMBL8511490 | 0.84 | DKK1 (0.42) | DKK1CA9CA2RARARARB | |
| SCHEMBL8515121 | 0.83 | DKK1 (0.38) | DKK1CA9CA2RARARARB | |
| SCHEMBL8515120 | 0.83 | DKK1 (0.38) | DKK1CA9CA2RARARARB | |
| Hydrochloric Acid SCHEMBL8515565 | 0.83 | DKK1 (0.41) | DKK1CA9CA2RARARARB | |
| SCHEMBL8513704 | 0.82 | RARA (0.40) | DKK1CA9CA2RARARARB | |
| SCHEMBL9612771 | 0.81 | RARA (0.41) | DKK1CA9CA2RARARARB | |
| Hydrochloric Acid SCHEMBL8667697 | 0.80 | RARA (0.41) | DKK1CA9CA2RARARARB | |
| SCHEMBL8514868 | 0.76 | DKK1 (0.64) | DKK1RARARARBPIK3CAPIK3CD | |
| SCHEMBL8512407 | 0.76 | ADRB1 (0.44) | DKK1RARARARBPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |