Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714985 | 0.82 | ABL1 (0.43) | PTGDR2KDM4ETYMPALPLCA12 | |
| SCHEMBL9715021 | 0.82 | PTGDR2 (0.39) | PTGDR2KDM4ERAB9ATYMPALPL | |
| Hydrochloric Acid SCHEMBL9715064 | 0.81 | PTGDR2 (0.39) | PTGDR2KDM4ERAB9ATYMPALPL | |
| SCHEMBL9715031 | 0.76 | PTGDR2 (0.38) | PTGDR2KDM4ERAB9ATP53POLB | |
| SCHEMBL27656187 | 0.73 | ALPL (0.43) | RAB9AALPLCA12 | |
| SCHEMBL22784034 | 0.72 | P2RX7 (0.47) | P2RX7KDM4ERAB9ATP53 | |
| SCHEMBL1361986 | 0.72 | TYMP (0.44) | KDM4ERAB9ATYMPALPLCA12 | |
| SCHEMBL9714973 | 0.71 | LMNA (0.42) | KDM4ETYMPALPLPOLB | |
| SCHEMBL16197762 | 0.71 | ALPL (0.46) | KDM4ERAB9ATYMPALPLCA12 | |
| SCHEMBL5023315 | 0.70 | ALPL (0.55) | KDM4ERAB9AALPLTP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |