Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.45 |
| ▸ | DKK1 | O94907 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | SORD | Q00796 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | NEK3 | P51956 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.34 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510840 | 0.89 | KMO (0.43) | KMODKK1LRRK2PIK3CASORD | |
| SCHEMBL8511790 | 0.87 | ROCK2 (0.41) | KMODKK1LRRK2PIK3CAMYLK4 | |
| SCHEMBL8510671 | 0.86 | DKK1 (0.44) | KMODKK1LRRK2PIK3CASORD | |
| Hydrochloric Acid SCHEMBL8511580 | 0.86 | ROCK2 (0.41) | KMODKK1LRRK2MYLK4STK17A | |
| Hydrochloric Acid SCHEMBL8512525 | 0.86 | ROCK2 (0.41) | KMODKK1LRRK2MYLK4STK17A | |
| SCHEMBL8512439 | 0.85 | DKK1 (0.56) | KMODKK1PIK3CASORDMTOR | |
| SCHEMBL8514889 | 0.84 | KMO (0.40) | KMODKK1LRRK2MTORCTSS | |
| Hydrochloric Acid SCHEMBL8513412 | 0.84 | DKK1 (0.55) | KMODKK1PIK3CASORDMTOR | |
| SCHEMBL8515556 | 0.84 | MEN1 (0.40) | KMODKK1LRRK2SORDSTK17A | |
| SCHEMBL8510713 | 0.84 | KMO (0.39) | KMODKK1LRRK2PIK3CASORD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |