Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.44 |
| ▸ | ITGAL | P20701 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512735 | 0.85 | GPR119 (0.48) | GPR119TBK1MAP4K4CKS1BSKP1 | |
| SCHEMBL2014735 | 0.85 | WNT3A (0.46) | GPR119CKS1BSKP1SKP2LRRK2 | |
| SCHEMBL2015994 | 0.84 | RARA (0.50) | GPR119MAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL2015241 | 0.83 | CKS1B (0.49) | GPR119MAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL2015195 | 0.82 | CKS1B (0.46) | GPR119MAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL12804909 | 0.82 | PIK3CA (0.48) | GPR119MAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL3270107 | 0.82 | MAP4K4 (0.50) | GPR119TBK1MAP4K4CKS1BSKP1 | |
| SCHEMBL3273530 | 0.82 | CKS1B (0.62) | GPR119TBK1MAP4K4CKS1BSKP1 | |
| SCHEMBL2015814 | 0.81 | ACHE (0.52) | GPR119TBK1CKS1BSKP1SKP2 | |
| SCHEMBL8513291 | 0.81 | GPR119 (0.52) | GPR119TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |