Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28762609 | 0.74 | NPC1 (0.39) | CA1CA2CA4POLBTDP1 | |
| SCHEMBL8516177 | 0.73 | CA2 (0.40) | CA1CA2CA4APEX1POLB | |
| SCHEMBL3478457 | 0.73 | SCN9A (0.49) | CA1CA2CA4CA9 | |
| SCHEMBL8593588 | 0.71 | ALDH1A1 (0.39) | CA1CA2POLBTDP1L3MBTL1 | |
| SCHEMBL8514468 | 0.71 | CYP3A4 (0.43) | CA1CA2CA4APEX1POLB | |
| SCHEMBL8298169 | 0.70 | MAPT (0.38) | POLBTDP1KDM4EALDH1A1MAPT | |
| SCHEMBL7952991 | 0.69 | APEX1 (0.67) | CA1CA2CA4APEX1POLB | |
| SCHEMBL8589908 | 0.69 | MAPT (0.38) | POLBTDP1KDM4EALDH1A1MAPT | |
| SCHEMBL8589906 | 0.69 | FTO (0.44) | POLBTDP1KDM4EALDH1A1MAPT | |
| SCHEMBL7812136 | 0.68 | ALDH1A1 (0.45) | TDP1L3MBTL1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457906-A1 | Derivatives of 1,2,4-benzothiadiazine dioxide, their preparation and use as allosteric modulators of the AMPA receptor | Universita'del Salento (IT) | 2012-05-30 | — | — | EP | disclosed |