Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8519376 | 0.92 | CCKBR (0.39) | AKT1NAMPTSIGMAR1CCKBRPDCD1 | |
| SCHEMBL8518880 | 0.79 | NAMPT (0.45) | AKT1NAMPTSIGMAR1MEN1KMT2A | |
| SCHEMBL7394047 | 0.71 | NAMPT (0.49) | NAMPTMEN1KMT2ACCKBRPDCD1 | |
| SCHEMBL21996778 | 0.70 | POLB (0.51) | AKT1NAMPTMEN1KMT2APDCD1 | |
| SCHEMBL7400533 | 0.67 | CCKBR (0.49) | NAMPTCCKBRPDCD1CD274BRD4 | |
| SCHEMBL3838871 | 0.66 | CA12 (0.63) | AKT1NAMPTMEN1KMT2AHDAC1 | |
| SCHEMBL21741848 | 0.65 | TDP1 (0.55) | NAMPTPOLBCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7241814 | 0.64 | HDAC1 (0.44) | AKT1NAMPTSIGMAR1CCKBRPDCD1 | |
| Propionamide SCHEMBL8144889 | 0.64 | CA12 (0.55) | AKT1NAMPTMEN1KMT2AHDAC1 | |
| Propionic Acid SCHEMBL8139542 | 0.64 | CA12 (0.61) | AKT1NAMPTMEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939412-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |