Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8401265 | 0.81 | ITGB3 (0.44) | PARP1PARP2 | |
| SCHEMBL8897079 | 0.80 | PARP1 (0.39) | CACNA1GCACNA1HCACNA1IPARP1PARP2 | |
| SCHEMBL8518279 | 0.79 | AKT1 (0.37) | NAMPTDRD2SIGMAR1MEN1KMT2A | |
| SCHEMBL7400352 | 0.73 | NAMPT (0.55) | NAMPTDRD2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL8519376 | 0.73 | CCKBR (0.39) | NAMPTDRD2SIGMAR1AKT1ALDH1A1 | |
| SCHEMBL7437642 | 0.67 | ITGB3 (0.65) | — | |
| SCHEMBL7437648 | 0.67 | ITGB3 (0.65) | — | |
| SCHEMBL3838871 | 0.66 | CA12 (0.63) | NAMPTMEN1KMT2AHDAC1AKT1 | |
| SCHEMBL7394047 | 0.66 | NAMPT (0.49) | NAMPTDRD2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL7241814 | 0.65 | HDAC1 (0.44) | NAMPTCACNA1GSIGMAR1HDAC1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939412-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |