Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518281 | 0.80 | HDAC1 (0.39) | NAMPTLMNAHDAC1POLBF2 | |
| SCHEMBL8519377 | 0.72 | BRD4 (0.39) | LMNAHDAC1POLBAKT1PDCD1 | |
| SCHEMBL8139001 | 0.67 | L3MBTL1 (0.49) | NAMPTHDAC1CA1CA2MEN1 | |
| SCHEMBL7400352 | 0.67 | NAMPT (0.55) | NAMPTHDAC1DRD2 | |
| SCHEMBL28619767 | 0.66 | HDAC1 (0.50) | NAMPTHDAC1CA1CA2 | |
| SCHEMBL7551243 | 0.65 | L3MBTL1 (0.51) | NAMPTLMNAHDAC1CA1CA2 | |
| SCHEMBL16192946 | 0.64 | NPC1 (0.58) | NAMPTHDAC1CA1HDAC6MEN1 | |
| SCHEMBL8372079 | 0.62 | L3MBTL1 (0.56) | NAMPTLMNAHDAC1CA1CA2 | |
| SCHEMBL3180689 | 0.62 | L3MBTL1 (0.61) | NAMPTHDAC1CA1CA2HDAC6 | |
| Propionamide SCHEMBL8144889 | 0.62 | CA12 (0.55) | NAMPTHDAC1AKT1CA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939412-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |