Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 3/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518281 | 0.92 | HDAC1 (0.39) | BRD4CREBBPCCKBRCD274PDCD1 | |
| SCHEMBL8518884 | 0.72 | NAMPT (0.42) | CD274PDCD1DRD2AKT1POLB | |
| SCHEMBL28246608 | 0.68 | CYP3A4 (0.49) | BRD4CREBBPGLSLMNA | |
| SCHEMBL7400533 | 0.67 | CCKBR (0.49) | BRD4CREBBPCCKBRCD274PDCD1 | |
| SCHEMBL31608963 | 0.64 | KMT2A (0.51) | BRD4CREBBPCCKBRCD274PDCD1 | |
| SCHEMBL3418637 | 0.64 | ALDH1A1 (0.62) | POLBKMT2ALMNA | |
| SCHEMBL13981921 | 0.63 | GLS (0.55) | BRD4CREBBPBRD9BAZ2BBAZ2A | |
| SCHEMBL21481482 | 0.63 | GLS (0.46) | BRD4CREBBPGLSHDAC1 | |
| SCHEMBL7017291 | 0.63 | GLS (0.46) | BRD4GLS | |
| SCHEMBL15151049 | 0.63 | CTSK (0.45) | BRD4GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939412-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |