Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518922 | 0.86 | ALDH1A1 (0.33) | KDM4EALDH1A1USP2KMT2AF2 | |
| SCHEMBL8519767 | 0.84 | AR (0.38) | ALDH1A1MAPK8PGRARCCNA2 | |
| SCHEMBL10975698 | 0.79 | PDK1 (0.43) | PGRAR | |
| SCHEMBL10984328 | 0.78 | AR (0.34) | PGRAR | |
| SCHEMBL10974442 | 0.77 | AR (0.32) | AR | |
| SCHEMBL8519174 | 0.69 | MAP4K1 (0.37) | KDM4EGAA | |
| SCHEMBL23070168 | 0.66 | LMNA (0.40) | KDM4EALDH1A1USP2GAAMAPT | |
| SCHEMBL8518907 | 0.66 | AR (0.46) | PGRAR | |
| SCHEMBL31382900 | 0.66 | TRPA1 (0.39) | KDM4EALDH1A1GAAGLAMAPT | |
| SCHEMBL10734596 | 0.64 | KDM4E (0.36) | KDM4EALDH1A1USP2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239776-A | Anti-androgenic amides | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-16 | — | — | US | claimed |
| EP-0002309-A2 | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-06-13 | — | — | EP | claimed |
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| US-4282218-A | ANTIANDROGENS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4239776-A | Anti-androgenic amides | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-16 | — | — | US | disclosed |
| EP-0002309-A2 | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-06-13 | — | — | EP | disclosed |