Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | ACLY | P53396 | 3/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8419412 | 0.86 | ALDH1A1 (0.43) | MAPTTSHRTP53SMN1; SMN2SLC22A12 | |
| SCHEMBL8421510 | 0.82 | SLC22A12 (0.39) | MAPTHPGDSLC22A12ALDH1A1LMNA | |
| SCHEMBL8421498 | 0.81 | ALDH1A1 (0.44) | MAPTTSHRHPGDALOX15SLC22A12 | |
| SCHEMBL8423191 | 0.81 | CCR2 (0.45) | MAPTTP53SLC22A12ALDH1A1LMNA | |
| SCHEMBL8421622 | 0.81 | ALDH1A1 (0.40) | MAPTTP53SMN1; SMN2SLC22A12ALDH1A1 | |
| SCHEMBL8424588 | 0.81 | TSHR (0.51) | MAPTTSHRHPGDALOX15SMN1; SMN2 | |
| SCHEMBL8095741 | 0.80 | PDE10A (0.43) | MAPTTSHRTP53HPGDALOX15 | |
| SCHEMBL8092688 | 0.80 | MAPK13 (0.43) | MAPTTSHRTP53HPGDALOX15 | |
| SCHEMBL8423226 | 0.80 | ALDH1A1 (0.48) | MAPTTP53ALOX15ALDH1A1LMNA | |
| SCHEMBL8420124 | 0.79 | ALDH1A1 (0.39) | MAPTTSHRSLC22A12ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |