Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8419412 | 0.90 | ALDH1A1 (0.43) | TSHRSLC22A12ALDH1A1MAPTKDM4E | |
| SCHEMBL8423191 | 0.86 | CCR2 (0.45) | SLC22A12ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL8421622 | 0.84 | ALDH1A1 (0.40) | SLC22A12ALDH1A1MAPTLMNAPPARG | |
| SCHEMBL8421072 | 0.84 | SQOR (0.47) | SLC22A12KMT2AMEN1MAP2K7MAP2K4 | |
| SCHEMBL8421510 | 0.82 | SLC22A12 (0.39) | SLC22A12ALDH1A1HPGDMAPTLMNA | |
| SCHEMBL8421498 | 0.81 | ALDH1A1 (0.44) | TSHRSLC22A12ALDH1A1HPGDMAPT | |
| SCHEMBL8519903 | 0.81 | MAPT (0.41) | TSHRSLC22A12ALDH1A1HPGDMAPT | |
| SCHEMBL8423226 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4ELMNAPOLB | |
| SCHEMBL8101739 | 0.79 | MAPK13 (0.54) | TSHRALDH1A1HPGDMAPTHIF1A | |
| SCHEMBL8420124 | 0.79 | ALDH1A1 (0.39) | TSHRSLC22A12ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |