SCHEMBL8521997

SCHEMBL8521997

CC1=Cc2cccc(-n3ccc4ccccc43)c2C1[Si](C)(C)C1C(C)=Cc2cccc(-n3ccc4ccccc43)c21

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BIRC5 O15392 1/20 0.33
CDC7 O00311 1/20 0.33
CDK2 P24941 1/20 0.33
ROCK1 Q13464 1/20 0.33
PRKD3 O94806 1/20 0.33
PRKCG P05129 1/20 0.33
PRKCB P05771 1/20 0.33
PRKCA P17252 1/20 0.33
PRKACA P17612 1/20 0.33
PRKACG P22612 1/20 0.33
PRKACB P22694 1/20 0.33
PRKCH P24723 1/20 0.33
PRKCI P41743 1/20 0.33
PRKCE Q02156 1/20 0.33
PRKCQ Q04759 1/20 0.33
PRKCZ Q05513 1/20 0.33
PRKCD Q05655 1/20 0.33
PRKD1 Q15139 1/20 0.33
TRAP1 Q12931 2/20 0.31
HSP90AA1 P07900 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3743352 0.80 BIRC5 (0.33) BIRC5CDC7CDK2ROCK1PRKD3
Hydrochloric Acid SCHEMBL7722791 0.78 CDC7 (0.34) BIRC5CDC7CDK2ROCK1PRKD3
SCHEMBL6657790 0.68 CYP1A2 (0.37) HSP90AA1
SCHEMBL3690934 0.68 BIRC5 (0.36) BIRC5CDC7CDK2ROCK1PRKD3
SCHEMBL5604900 0.67 BIRC5 (0.47) BIRC5CDC7CDK2ROCK1PRKD3
SCHEMBL29896751 0.67 BIRC5 (0.47) BIRC5CDC7CDK2ROCK1PRKD3
SCHEMBL8934717 0.67 ALDH1A1 (0.46) BIRC5CDC7CDK2ROCK1PRKD3
SCHEMBL28798217 0.64 CDC7 (0.46) BIRC5CDC7CDK2ROCK1PRKD3
SCHEMBL8575892 0.64 ENPP3 (0.34)
SCHEMBL2187570 0.64 BIRC5 (0.47) BIRC5CDC7CDK2ROCK1PRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5942459-A ALUMOXANE-FREE MIXTURE OF TRANSITION METAL METALLOCENE, ORGANOALUMINUM COMPOUND, BORIC ACID-CONTAINING POWDER MITSUBISHI CHEMICAL CORPORATION (JP) 1999-08-24 US disclosed
EP-0728773-B1 Catalysts for olefin polymerization and a process for preparing olefin polymers therewith MITSUBISHI CHEM CORP (JP) 1998-11-04 EP disclosed
EP-0728773-A1 Catalysts for olefin polymerization and a process for preparing olefin polymers therewith MITSUBISHI CHEMICAL CORPORATION (JP) 1996-08-28 EP disclosed