Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.61 |
| ▸ | PDE4A | P27815 | 12/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6272301 | 0.99 | ADORA2B (0.64) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4384741 | 0.99 | ADORA2B (0.64) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8536009 | 0.99 | ADORA2B (0.64) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL258898 | 0.97 | ADORA2B (0.62) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6272735 | 0.96 | PDE4A (0.59) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| Acetic Acid SCHEMBL4280720 | 0.93 | ADORA2B (0.57) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL667797 | 0.90 | PDE4A (0.60) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL874737 | 0.84 | ADORA2A (0.56) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28721443 | 0.83 | CDK1 (0.53) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3671339 | 0.82 | DPP4 (0.44) | ADORA2BPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234585-A | Microtubule-associated protein TAU (MAPT) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-115298312-A | Leucine-rich repeat kinase 2 (LRRK 2) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-114796255-A | Application of nicotinamide mononucleotide in protecting liver from being damaged | 深圳市旷逸生物科技有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-114728018-A | Huntington (HTT) iRNA pharmaceutical compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-110218727-A | For treating the exon skipping composition of muscular dystrophy | 萨勒普塔医疗公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-110066793-A | For treating amyotrophic exon skipping composition | 萨勒普塔医疗公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-105378081-B | Exon skipping compositions for the treatment of muscular dystrophy | 萨勒普塔医疗公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-105392884-B | Exon skipping compositions for the treatment of muscle atrophy | 萨勒普塔医疗公司 | 2018-11-30 | — | — | CN | disclosed |
| EP-0704445-B1 | Preparation of N-9 substituted guanine compounds | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| US-5565565-A | Preparation of N-9 substituted guanine compounds | SYNTEX (U.S.A.) INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0704445-A1 | Preparation of N-9 substituted guanine compounds | F. Hoffmann-La Roche AG (CH) | 1996-04-03 | — | — | EP | disclosed |
| EP-0590361-A1 | Process for the preparation of 2-amino-6-halopurines | BASF Aktiengesellschaft (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-4914131-A | HERPES SIMPLEX VIRUS; LIDOCAINE OR ITS SALTS | Brigham, Dana P. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4757088-A | Administering lidocaine and pantothenic acid; herpes | Brigham, Dana P. (US) | 1988-07-12 | — | — | US | disclosed |
| US-4628063-A | LIDOCAINE, PANTOTHENOL, HERPES | Brigham, Dana P. (US) | 1986-12-09 | — | — | US | disclosed |